PGT-SR, also called structural rearrangement testing, is a genetic screening procedure used alongside in vitro fertilization (IVF). It specializes in figuring out structural chromosomal abnormalities inside embryos, consisting of translocations, inversions, or deletions. Detecting those problems permits us to choose embryos that have a higher chance of implantation and a decrease danger of chromosomal disorders.

PGT-SR, preimplantation genetic checking out for structural chromosomal rearrangements, is a genetic check finished on embryos created thru IVF to screen for chromosomal structural rearrangements typically caused by balanced translocations and inversions. Chromosomal rearrangements may be inherited or may additionally arise spontaneously (de novo). It is estimated that 1 in every 500 human beings carry a balanced reciprocal translocation. Most are them are not aware of of their balanced translocation carrier repute and live everyday healthful lives. A person usually aware once they are trying to have kids.Bottom of Form

Steps of the PGT-SR Procedure in Simple Terms
⦁ IVF Process – In the process of In Vitro Fertilization, Our doctors in Aspire Fertility will collect eggs from the woman and mix with the sperm in a lab to create a healty embryos.
⦁ Embryo Biopsy – This process will take about five or six days, the embryos will grow into a more advanced stage called a blastocyst. At this point, Our doctors carefully take a tiny sample of cells from each embryo and we make sure it won’t hurt the embryo, and it keeps growing normally in our lab
⦁ Genetic Testing – The cells taken from the embryos will be sent to the lab for testing. Scientists check to see if there are any issues with the chromosomes, like missing or extra pieces. This helps identify the health embryos and unhealthy embryos which have problems.
⦁ Choosing the Best Embryos – Based on the lab results, our doctors will pick only the embryos with the right structure of chromosomes. These are so called healthy chromosomes most likely to lead to a healthy pregnancy.
Transferring Healthy Embryos – Finally, the best embryos are placed into the woman’s uterus. This step gives the best chance for a successful pregnancy and a healthy baby.

⦁ What does PGT-SR stand for and who should think about for PTG-SR
PGT-SR means Preimplantation Genetic Examining for Architectural Rearrangements. If a person has an unusual arrangement of chromosomes so called structural arrangement, which results causing problem between eggs and sperms during fertilization.


You might consider if
You’ve had numerous miscarriages– If you have actually lost maternities greater than as soon as, it could be due to a chromosome issue.
You’ve had several failed IVF therapies– If IVF keeps stopping working, chromosome issues in the embryos could be the reason.
You or your companion have an unusual chromosome plan– Some people have chromosomes that are reorganized in different ways (without knowing it). This doesn’t influence them, yet it can cause problems when trying to have an infant, resulting in miscarriages or hereditary problems.
PGT-SR helps by examining embryos throughout IVF and choosing the ones with the correct chromosome structure, enhancing the possibilities of a healthy pregnancy.

 
PGT-SR

Dr. Ashwini G. B.

MBBS, MS (OBG), FIRM ( Fellowship in Reproductive Medicine ), Embryology Certification as Clinical Embryologist

Dr. Ashwini G. B. holds her MBBS from JJMMC Davangere, MS in Gynaecology from KMC Manipal in the year 2006 where she was Gold medalist & Best Outgoing Student of the Batch. She received her ESHRE (European Society of Human Reproduction & Embryology) Certification as a Clinical Embryologist in 2021. She carries over 21 years of experience and her special interests include PCOS, Embryo Testing (invasive and non-invasive) and Embryo Implantation.


PGT-SR

Dr. Vanajakshi H. N.

MBBS.DGO – Obstetrics & Gynaecology, Consultant

Dr. Vanajakshi is an experienced Fertility Specialist with over 15+ years of experience in Gynaecology and infertility treatment. She received her MBBS from AIMS, Mandya in 1998 passing out as a Gold Medalist in Microbiology. She pursued her MRCOG in 2004 and received her DGO in Obstetrics & Gynaecology in 2014 from Vydehi Institute of Medical Science & Research Center followed by the Fellowship in Reproductive Medicine from Rajiv Gandhi University of Health Sciences (RGHUS), Bangalore. Dr. Vanajakshi’s specialties include Infertility Treatment and High-Risk Pregnancies. Outside of work she enjoys reading, gardening, playing chess and volunteering in community services.

1. Who should consider PGT-SR?

PGT-SR is recommended for individuals or couples with a history of recurrent miscarriages, repeated IVF failures, or known structural chromosomal rearrangements.

2. Is PGT-SR safe for embryos?
✅ Yes, it’s safe!

Think of an embryo like a tiny, expanding seed. Doctors take an extremely little piece from the external shell of the embryo– kind of like taking a little fallen leave from a plant without harming the seed itself. This test helps inspect if the embryo’s “DNA user’s manual” (chromosomes) is appropriate prior to placing it in the womb.

3. Can PGT-SR ensure a healthy and balanced pregnancy?
No Always, but it helps a great deal!
PGT-SR considerably reduces the chance of troubles, yet pregnancy still depends upon various other points like:.

4. Does PGT-SR mean you require extra IVF cycles?
PGT-SR adds an additional step to the IVF procedure, which can make it somewhat more expensive. It’s like selection of the healthiest embryos from the beginning to avoid unsuccessful maternities.

Example : if you pick an apple from a tree without checking might end up with spoiled or poor ones but let say if you spend some time to find the best apple from the same tree you’ll have good ones from the start! PGT-SR assists pick the best embryo to boost the possibility of success.

5. Just how does PGT-SR boost pregnancy chances?
It assists by picking embryos with the appropriate chromosomes!

When embryos have missing out on or extra chromosomes, it can lead to losing the unborn babies or genetic disorders. PGT-SR checks the embryos prior to implantation, making certain only the ones with normal chromosomes are made use of. This boosts the opportunity of a successful pregnancy.

Instance: Think about a dish publication. If the pages are blended or missing out on, the recipe won’t function. Yet if guide is complete and in order, the recipe ends up great! PGT-SR aids choose embryos with the appropriate “recipe” (chromosomes) so the baby can develop correctly.

PGT-SR

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PGT-SR

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