PGT-SR

PGT-SR, also known as structural rearrangement testing, is an advanced genetic screening procedure used alongside in vitro fertilization (IVF). It focuses on identifying structural chromosomal abnormalities within embryos, including translocations, inversions, or deletions. Detecting these issues allows us to select embryos that have a higher chance of implantation and a lower risk of chromosomal disorders.

PGT-SR, preimplantation genetic testing for structural chromosomal rearrangements, is a genetic test performed on embryos created through IVF to screen for chromosomal structural rearrangements normally caused by balanced translocations and inversions. Chromosomal rearrangements can be inherited or may occur spontaneously (de novo). It is estimated that 1 in every 500 people carry a balanced reciprocal translocation. Most are unaware of their balanced translocation carrier status and live normal healthy lives. A person typically becomes aware of their carrier status once they try to have children.

The PGT-SR procedure comprises several key steps:

IVF Process: Eggs are retrieved and fertilized through IVF, resulting in multiple embryos.

Embryo Biopsy: On the fifth or sixth day of development, when embryos reach the blastocyst stage, a few cells are carefully extracted from each embryo.

Genetic Analysis: The extracted cells undergo thorough genetic analysis to detect structural chromosomal rearrangements.

Embryo Selection: Embryos that are found to be structurally normal are chosen for transfer into the uterus.

Transferring Healthy Embryos: Only embryos without structural chromosomal issues are transferred, increasing the likelihood of a successful pregnancy.

1. Who should consider PGT-SR?

PGT-SR is recommended for individuals or couples with a history of recurrent miscarriages, repeated IVF failures, or known structural chromosomal rearrangements.

2. Is PGT-SR safe for embryos?

Yes, PGT-SR is a safe and established procedure with minimal impact on embryo development.

3. Can PGT-SR guarantee a healthy pregnancy?

While it significantly reduces the risk of structural chromosomal disorders, success depends on various factors, including embryo quality and maternal health.

4. Does PGT-SR require additional IVF cycles?

PGT-SR involves one extra step during the IVF process, which may result in slightly higher costs but can substantially improve the chances of a healthy pregnancy.

5. How does PGT-SR enhance fertility outcomes?

PGT-SR ensures that only embryos without structural chromosomal abnormalities are transferred, reducing the risk of genetic disorders in offspring.